Factory Supply High Quality 99% Terbinafine HCl /Terbinafine Hydrochloride /CAS 78628-80-5
| name | Terbinafine Hydrochloride |
| CAS | 78628-80-5 |
| EINECS | 245-385-8 |
| MF | C21H26ClN |
| MW | 327.89 |
| MP | 204-208°C |
| Storage. temp | -20°C Freezer |
| Assay | 99% Min. |
Terbinafine hydrochloride a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Terbinafine·HCl a member of the allylamine class of antifungals, has been found to be a specific inhibitor of ergosterol synthesis via squalene epoxidase inhibition. Squalene epoxidase is an enzyme released by the dermatophyte fungi to break down Squalene, which interferes with cell membrane function and wall synthesis. Additionally, Terbinafine has also been reported to suppress cell proliferation in vitro and in vivo through inhibition of DNA synthesis and apoptosis activation. It has also been noted that by pretreating of cells with a p21 specific antisense oligonucleotide the Terbinafine induced inhibition of cell growth can be reversed.
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Factory Supply High Quality 99% Terbinafine HCl /Terbinafine Hydrochloride /CAS 78628-80-5
| name | Terbinafine Hydrochloride |
| CAS | 78628-80-5 |
| EINECS | 245-385-8 |
| MF | C21H26ClN |
| MW | 327.89 |
| MP | 204-208°C |
| Storage. temp | -20°C Freezer |
| Assay | 99% Min. |
Terbinafine hydrochloride a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Terbinafine·HCl a member of the allylamine class of antifungals, has been found to be a specific inhibitor of ergosterol synthesis via squalene epoxidase inhibition. Squalene epoxidase is an enzyme released by the dermatophyte fungi to break down Squalene, which interferes with cell membrane function and wall synthesis. Additionally, Terbinafine has also been reported to suppress cell proliferation in vitro and in vivo through inhibition of DNA synthesis and apoptosis activation. It has also been noted that by pretreating of cells with a p21 specific antisense oligonucleotide the Terbinafine induced inhibition of cell growth can be reversed.
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