1.Bulk minoxidil can Stimulate the proliferation and differentiation of hair follicle epithelial cells
Bulk minoxidil is an active metabolite that stimulates hair growth. Bulk minoxidil disolved in water can increase the amount of synthesis of dermal papilla, hair mother material, outer hair root sheath and fiber cells around hair, thereby extending hair growth period and promoting the transformation of a hair to final hair.
2. Bulk minoxidil can Promote angiogenesis
The mRNA expression of vascular endothelial cell growth factor is different in different growth cycles of hair. In the growth phase, the mRNA of vascular endothelial cell growth factor is strongly expressed in dermal papilla cells, but it is less expressed in the degenerative and resting phases.Experiments showed that bulk minoxidil increased the expression of vascular endothelial cell growth factor mRNA and its protein in a dose-dependent manner, thereby promoting the formation of dermal papilla vessels and increasing the local blood supply.
3. Bulk minoxidil can Open potassium channel
The opening of potassium channels is an important step to regulate hair growth. Bulk minoxidil is an activator of potassium channels, which can increase the permeability of potassium ions and prevent calcium ions from flowing into human cells. As a result, the concentration of free calcium ions in cells decreases.