Feline infectious peritonitis (FIP) 20 concentration 5.5 ml, intraperitoneal injection for dry and wet FIP, reducing abdominal fluid, nutritional solution for cats with big bellies.
Product Description
High Quality FIPV 5ml /6ml/7mlTreatment of Cats with Naturally Occurring Feline Infectious Peritonitis.
| Name | GS-441524 treatment of cats with naturally occurring feline infectious peritonitis. |
| Target Activity | FIPV:0.78 μM (EC50) |
| activity | Four of the 31 cats that presented with severe disease died or were euthanized within 2-5 days and a fifth cat after 26 days. The 26 remaining cats completed the planned 12 weeks or more of treatment(GS-441524). Eighteen of these 26 cats remain healthy at the time of publication after one round of treatment, while eight others suffered disease relapses within 3-84 days. Six of the relapses were non-neurological and two neurological. Three of the eight relapsing cats were treated again at the same dosage, while five cats had the dosage increased from 2.0 to 4.0 mg/kg q24h. The five cats treated a second time at the higher dosage, including one with neurological disease, responded well and also remain healthy . However, one of the three cats re-treated at the original lower dosage relapsed with neurological disease and was euthanized, while the two remaining cats responded favorably but relapsed a second time. These two cats were successfully treated a third time at the higher dosage, producing 25 long-time survivors. One of the 25 successfully treated cats was subsequently euthanized due to presumably unrelated heart disease, while 24 remain healthy[1]. |
| animal experiment | Cats ranged from 3.4-73 months of age (mean 13.6 months); 26 had effusive or dry-to-effusive FIP and five had non-effusive disease. Cats with severe neurological and ocular FIP were not recruited. The group was started on GS-441524 at a dosage of 2.0 mg/kg SC q24h for at least 12 weeks and increased when indicated to 4.0 mg/kg SC q24h[1]. |
| other name | GS 441524 triphosphate |
| FW | 291.26 |
| FM | C12H13N5O4 |
| CAS No. | 1191237-69-0 |
Store
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility
DMSO: 50 mg/mL (171.66 mM)
solution formulation table
| optional solvent | solubility体积质量 | 1 mg | 5 mg | 10 mg | 25 mg |
| DMSO | 1 mM | 3.4334 mL | 17.1668 mL | 34.3336 mL | 85.834 mL |
| 5 mM | 0.6867 mL | 3.4334 mL | 6.8667 mL | 17.1668 mL | |
| 10 mM | 0.3433 mL | 1.7167 mL | 3.4334 mL | 8.5834 mL | |
| 20 mM | 0.1717 mL | 0.8583 mL | 1.7167 mL | 4.2917 mL | |
| 50 mM | 0.0687 mL | 0.3433 mL | 0.6867 mL | 1.7167 mL | |
| 100 mM | 0.0343 mL | 0.1717 mL | 0.3433 mL | 0.8583 mL |
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