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Supply GTS-21 Powder CAS#156223-05-1 with Bulk Price And Safe Delivery

Supply GTS-21 Powder CAS#156223-05-1 with Bulk Price And Safe Delivery, find complete details about Supply GTS-21 Powder CAS#156223-05-1 with Bulk Price And Safe Delivery, GTS-21, GTS-21 supplier, GTS-21 chemical matrial - Multinpharma

Model:
156223-05-1
Brand:
MT
Code:
156223-05-1
CAS.NO:
156223-05-1

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Product Description

Supply GTS-21 Powder CAS#156223-05-1 with Bulk Price And Safe Delivery

Common Name	GTS-21
CAS Number	156223-05-1	Molecular Weight	381.30
Density	1.1±0.1 g/cm3	Boiling Point	485.6±45.0 °C at 760 mmHg
Molecular Formula	C19H22Cl2N2O2	Melting Point	216-217℃ (decomposition)
MSDS	USA	Flash Point	247.5±28.7 °C

Use of GTS-21

GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation. Target: nAChRin vitro: GTS-21 is one of the most potent α7nAChR agonists, has been reported to attenuate pro-inflammatory cytokine production, improve outcomes in sepsis models, pancreatitis, and ischemia-reperfusion injury, and inhibit the production of endotoxin-induced TNF in lung tissue. In addition, recent studies have demonstrated that GTS-21 inhibits the activities of endothelial cells and monocyte macrophages, as well as the secretion of pro-inflammatory cytokines in peripheral blood samples, by regulating the JAK2-STAT3 pathway. [1] in vivo: In septic animals, GTS-21 significantly ameliorated GI motility, lowered systemic and colonic levels of IL-6, decreased colonic permeability, and decreased the number of positive cultures obtained from blood and mesenteric lymph nodes. Splenectomy prevented animals from developing sepsis-induced ileus. Chrna7 mice displayed a more severe septic phenotype, whereas GTS-21 remarkably was also beneficial in these animals.

Common Name	GTS-21
CAS Number	156223-05-1	Molecular Weight	381.30
Density	1.1±0.1 g/cm3	Boiling Point	485.6±45.0 °C at 760 mmHg
Molecular Formula	C19H22Cl2N2O2	Melting Point	216-217℃ (decomposition)
MSDS	USA	Flash Point	247.5±28.7 °C