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Prilocaine CAS#721-50-6 For Prilocaine Basic Information Local Anesthetic Drug
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Prilocaine CAS#721-50-6 For Prilocaine Basic Information Local Anesthetic Drug

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PRILOCAINE CAS#721-50-6 For Tato, find complete details about PRILOCAINE CAS#721-50-6 For Tato, PRILOCAINE, CAS#721-50-6, Tato Chemical - Multinpharma
  • Cas 721-50-6
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  • 721-50-6
  • 721-50-6

 

the structural formula of prilocaine


Prilocaine Chemical Properties
Melting point  37-38°
Boiling point  bp0.1 159-162°
density  1.0117 (rough estimate)
refractive index  nD20 1.5298
solubility  Slightly soluble in water, very soluble in acetone and in ethanol (96 per cent).
form  neat
pka pKa 7.32 or 7.89 (Uncertain)
Water Solubility  6.169g/L(25 ºC)
InChIKey MVFGUOIZUNYYSO-UHFFFAOYSA-N
CAS DataBase Reference 721-50-6(CAS DataBase Reference)
NIST Chemistry Reference Propanamide, n-(2-methylphenyl)-2-(propylamino)-(721-50-6)

Safety Information
HS Code  2924296000
Hazardous Substances Data 721-50-6(Hazardous Substances Data)



Usage:

Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lidocaine but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lidocaine. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed to use adrenaline. 
[Pharmacological] its 3% solution has a similar local anesthesia efficacy as the anesthesia drug of 2% lidocaine together with adrenaline. It has a slow onset time which lasts about 6~7min and the duration time of about 1.5~2h. It has a strong penetration capability through mucous membranes. Adrenaline has a slightly prolonged duration of action. PPB is 55% and T1/2 of about 1.5h. It is subject to liver metabolism with its metabolites nitroso toluidine being able to oxidize hemoglobin to form methemoglobin. It can be transported to the fetus through the placenta. 
[Adverse reactions] once the usage amount exceeds 600mg, methaemoglobinaemia can occur with cyanosis, tachycardia, headache, dizziness and weakness occurring. 
[Note] patients of anemia, congenital or acquired methaemoglobinaemia, respiratory failure or heart failure and hypoxic patients should be disabled. It is forbidden for applied to obstetric anesthesia. 
[Usage and dosage] infiltration anesthesia: 0.5% to 1% solution with the duration of action of 1 to 1.5 hours.
Nerve blocking anesthesia: use 1% to 2% solution with the duration of action being 2-3 hours.
Epidural anesthesia: use10 to 30 mL of 1.5%~1% solution with the duration of action of 2.5 to 3.5 hours. Use a maximum dose of 600 mg.



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