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Dosage and Use of Afoxolaner for Dog, Cat and Other Poultry Animals Afoxolaner
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Dosage and Use of Afoxolaner for Dog, Cat and Other Poultry Animals Afoxolaner
Dosage and Use of Afoxolaner for Dog, Cat and Other Poultry Animals Afoxolaner Dosage and Use of Afoxolaner for Dog, Cat and Other Poultry Animals Afoxolaner
Dosage and Use of Afoxolaner for Dog, Cat and Other Poultry Animals Afoxolaner Dosage and Use of Afoxolaner for Dog, Cat and Other Poultry Animals Afoxolaner
Dosage and Use of Afoxolaner for Dog, Cat and Other Poultry Animals Afoxolaner Dosage and Use of Afoxolaner for Dog, Cat and Other Poultry Animals Afoxolaner
Dosage and Use of Afoxolaner for Dog, Cat and Other Poultry Animals Afoxolaner Dosage and Use of Afoxolaner for Dog, Cat and Other Poultry Animals Afoxolaner
Dosage and Use of Afoxolaner for Dog, Cat and Other Poultry Animals Afoxolaner Dosage and Use of Afoxolaner for Dog, Cat and Other Poultry Animals Afoxolaner

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Dosage and Use of Afoxolaner for Dog, Cat and Other Poultry Animals Afoxolaner

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Poultry Animals Afoxolaner, Afoxolane, Afoxolane supplier, cas1093861-60-9 - Multinpharma

  • 1093861-60-9

  • MT

  • 1093861-60-9

  • 1093861-60-9

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afoxolaner insecticide for Dog ,CAT animal with Best Price


Common Name Afoxolaner
CAS Number 1093861-60-9 Molecular Weight 625.87000
Density N/A Boiling Point N/A
Molecular Formula C26H17ClF9N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

Use of Afoxolaner


Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2].

Afoxolaner Biological Activity

Description Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2].
Related Catalog
Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel
Research Areas >> Infection
Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vivo A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30[1].
References

[1]. Mitchell EB, et al. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.Vet Parasitol. 2014 Apr 2;201(3-4):223-5.

[2]. Beugnet F, et al. Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs.Parasite. 2014;21:42.

 Chemical & Physical Properties

Molecular Formula C26H17ClF9N3O3
Molecular Weight 625.87000
Exact Mass 625.08100
PSA 79.79000
LogP 6.71990
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